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KMID : 0382420010270010106
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Korean Journal of Environmental Health Society
2001 Volume.27 No. 1 p.106 ~ p.111
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Synthesis and Antibacterial Activity of Polyacrylic Acid ( PAA ) - Sulfacetamide
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Kim Jong-Woan
Lee Woo-Yoon
Kim Yong-Yeul
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Abstract
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Recently there were many studies not only to enhance drug delivery effect but to reduce side effect. Drug delivery system is able to improve efficiency with decreasing side effect of drug dosage. It made possibility to use for a long term. Polymer drug was prepared by acid halide method with polymer in such of polyacylic acid and sulfacetaminde. Its chemical properties were identified by means of IR, TGA. The antibacterial activities of polymer drug were studied by MICs and disk susceptibility test. The antibacterial activities by clean zone were increased in order of Staphyloccus aures < Escherichia Coli. < Streptococcus pyrogenes < Pseudomonas aeruginosa at disk susceptibility test. The antibacterial activities of polymer drug against variety bacillus were excellent compared to those of control drug such as sulfacetamide.
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